Overview

Polynucleotides, often referred to as PN or PDRN, are emerging as a popular injectable treatment known for their skin-boosting and regenerative capabilities. While they have gained traction in the aesthetic field in recent years, polynucleotides have been utilised in medical applications since the 1980s, primarily for treating joint issues.

Polynucleotides consist of chains of nucleotides, the essential building blocks of DNA and RNA. In aesthetic applications, these compounds are commonly derived from the sperm of salmon or trout. Once extracted, they undergo a rigorous process of purification and sterilization to ensure safety and effectiveness for medical use.

Polynucleotides are strands of DNA and RNA. The most notable source of polynucleotides used in cosmetic treatments for the skin and hair, is salmon or trout sperm, because it is rich in polynucleotides and compatible with human skin. In the context of skin rejuvenation, polynucleotides have gained popularity due to their remarkable regenerative properties and ability to enhance skin health

Polynucleotides work by stimulating cellular regeneration and repair mechanisms in the skin. These naturally occurring molecules, command the body's own cells to produce collagen and elastin—two integral proteins that help maintain skin structure, elasticity, and overall health. When polynucleotides are injected into the skin, they enhance hydration by attracting and retaining water molecules, resulting in a plumper, more youthful appearance. Additionally, they exhibit anti-inflammatory properties, which can help soothe redness and irritation, making them beneficial for various skin types, including sensitive skin.

Polynucleotides are primarily used to treat:

  • Signs of Aging: They help reduce fine lines and wrinkles, improving overall skin texture and firmness.
  • Skin Laxity: By stimulating collagen and elastin production, polynucleotides effectively firm sagging areas.
  • Hydration: They enhance skin hydration, making them ideal for addressing dry or dehydrated skin.
  • Post-Treatment Recovery: They can aid in healing and rejuvenation following cosmetic procedures such as microneedling or laser treatments.
  • Scarring and Skin Damage: Polynucleotides can improve the appearance of stretch marks, surgical scars and acne scars and promote more even skin tone.

Where can they be used?

Polynucleotides can be used on skin, pretty much anywhere on the face or body.

Patients often notice initial improvements in skin hydration and texture within a few days following treatment. However, significant results, including enhanced skin firmness and reduction of wrinkles, typically manifest over a period of 4 to 12 weeks as the collagen and elastin production takes effect.

Polynucleotide treatments are suitable for a wide range of individuals, particularly those seeking to rejuvenate their skin and address signs of aging. However, certain individuals may not be suitable candidates:

  • Health Risks: Those with active infections, autoimmune disorders, or allergies to any components of the treatment should consult a healthcare professional for advice.
  • Skin Types: While generally safe for all skin types, individuals with specific skin concerns, particularly sensitive skin or certain inflammatory conditions, should discuss these with their practitioner before proceeding.
  • Expectations: It is essential to have realistic expectations about the results, and an initial consultation will help clarify what can be achieved based on individual needs.

Polynucleotides are considered safe for cosmetic use due to their biocompatible nature. They are derived from natural sources, minimizing the risk of allergic reactions or adverse side effects. Minimal side effects such as mild swelling, redness, or bruising at the injection site are common but typically resolve quickly. Choosing a skilled practitioner who uses high-quality, clinically tested polynucleotide products further enhances safety and effectiveness, ensuring adherence to best practices in hygiene and patient care.

The majority of patients report some discomfort during polynucleotide treatments. Practitioners often apply a topical anaesthetic prior to injections to enhance comfort. While some individuals may experience a stinging or pinching sensation during the procedure, this is usually well-tolerated.

Results from polynucleotide treatments can last between six months to a year, depending on individual factors such as age, skin type, and lifestyle choices. Regular maintenance treatments are recommended every 6 to 12 months to sustain the results and continue improving skin quality over time. Engaging in a consistent skincare routine and protecting the skin from sun exposure can also help prolong the effectiveness of the treatment.

The cost of polynucleotide treatments can vary significantly based on factors such as geographical location, the experience of the practitioner, and the specific areas being treated. On average, prices typically range from £250 to £500 per session. Different clinics may offer package deals or discounts for multiple sessions, so it is advisable to discuss pricing openly with your practitioner during your initial consultation.

At Save Face, we take the guess work out of selecting a non-surgical cosmetic practitioner. We know what to check and how to check it. All of the practitioners you will find using the Save Face search engine have passed a rigorous 116 point assessment process to ensure that: 

  • They are who they say they are
  • They are a registered nurse/midwife, doctor, dentist or prescribing pharmacist with specialist training and insurance in each treatment listed on their profile
  • They use licensed products sourced from reputable suppliers
  • They have all of the necessary paperwork in place to protect you from undue risk and harm
  • Their clinic is safe and hygienic

Click here to find your nearest Save Face accredited practitioner

Subscribe to our newsletter to receive the latest news & updates